Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aminopeptidase N | 0.1908 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0562 | 0 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0562 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.171 | 0.8533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1346 | 0.5828 | 0.683 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0562 | 0 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0562 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0562 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0562 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0562 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0562 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.1544 | 0.7295 | 0.8549 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0562 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0562 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0562 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0562 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0562 | 0 | 0.5 |
Onchocerca volvulus | 0.1908 | 1 | 1 | |
Entamoeba histolytica | aminopeptidase, putative | 0.0562 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.1908 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | < 10 % | Growth inhibition of human MCF7 cells at 10 uM after 72 hrs by MTT assay relative to control | ChEMBL. | 23747810 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.