Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0281 | 0.9081 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0128 | 0.2968 | 0.0146 |
Brugia malayi | Protein kinase domain containing protein | 0.0281 | 0.9081 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0128 | 0.2968 | 0.0146 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0067 | 0.0545 | 0.5 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0304 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0281 | 0.9081 | 1 |
Echinococcus granulosus | insulin receptor | 0.0281 | 0.9081 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0281 | 0.9081 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.3979 | 0.1655 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0304 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0281 | 0.9081 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0281 | 0.9081 | 1 |
Onchocerca volvulus | 0.0067 | 0.0545 | 1 | |
Echinococcus multilocularis | insulin receptor | 0.0281 | 0.9081 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0155 | 0.407 | 0.1803 |
Schistosoma mansoni | tyrosine kinase | 0.0128 | 0.2968 | 0.0146 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 37 uM | Inhibition of human recombinant His-tagged c-MET kinase using 5FAM-KKKSPGEYVNIGFG-NH2 as substrate after 60 mins by TR-FRET assay | ChEMBL. | 23702473 |
IC50 (functional) | = 105.6 uM | Cytotoxicity against human MKN45 cells after 1 hr by Western blotting analysis | ChEMBL. | 23702473 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.