Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | voltage-dependent calcium channel beta 2a subunit | 0.0885 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0165 | 0.1061 | 0.0298 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.0068 | 0.0156 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0157 | 0.096 | 0.2212 |
Schistosoma mansoni | serine-rich repeat protein | 0.0085 | 0.0068 | 0.0156 |
Echinococcus multilocularis | high voltage activated calcium channel beta | 0.0429 | 0.4341 | 1 |
Echinococcus granulosus | high voltage activated calcium channel beta | 0.0429 | 0.4341 | 1 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0159 | 0.0977 | 0.2251 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0157 | 0.096 | 0.2212 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0165 | 0.1061 | 0.0298 |
Schistosoma mansoni | voltage-gated cation channel | 0.0157 | 0.096 | 0.2212 |
Schistosoma mansoni | high voltage-activated calcium channel beta subunit 2 | 0.0429 | 0.4341 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0364 | 0.3524 | 0.7583 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0364 | 0.3524 | 0.7583 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.