Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | histone deacetylase, putative | 0.0433 | 0.0142 | 0.1224 |
Leishmania major | histone deacetylase, putative | 0.1096 | 0.1159 | 1 |
Echinococcus multilocularis | stromal interaction molecule 1 | 0.1517 | 0.1805 | 0.1805 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.1096 | 0.1159 | 0.1159 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0433 | 0.0142 | 0.1224 |
Echinococcus granulosus | calcium release activated calcium channel | 0.6854 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0695 | 0.0543 | 0.0543 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.6854 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.1096 | 0.1159 | 0.1159 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0433 | 0.0142 | 0.0142 |
Echinococcus granulosus | stromal interaction molecule 1 | 0.1517 | 0.1805 | 0.1805 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1096 | 0.1159 | 0.5 |
Echinococcus granulosus | histone deacetylase 7 | 0.0433 | 0.0142 | 0.0142 |
Brugia malayi | Histone deacetylase family protein | 0.0433 | 0.0142 | 0.0142 |
Echinococcus multilocularis | histone deacetylase | 0.0433 | 0.0142 | 0.0142 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.1096 | 0.1159 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1096 | 0.1159 | 0.1159 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0433 | 0.0142 | 0.1224 |
Plasmodium vivax | histone deacetylase, putative | 0.0433 | 0.0142 | 0.1224 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0433 | 0.0142 | 0.1224 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0433 | 0.0142 | 0.0142 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0433 | 0.0142 | 0.1224 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1096 | 0.1159 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.1096 | 0.1159 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0433 | 0.0142 | 0.0142 |
Trypanosoma brucei | histone deacetylase 1 | 0.1096 | 0.1159 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.1096 | 0.1159 | 0.1159 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0453 | 0.0173 | 0.0173 |
Trypanosoma brucei | histone deacetylase 4 | 0.0433 | 0.0142 | 0.1224 |
Plasmodium falciparum | histone deacetylase 1 | 0.1096 | 0.1159 | 1 |
Schistosoma mansoni | histone deacetylase | 0.1096 | 0.1159 | 0.1159 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1096 | 0.1159 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0433 | 0.0142 | 0.0142 |
Schistosoma mansoni | Protein orai-1 | 0.6854 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1096 | 0.1159 | 0.5 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0453 | 0.0173 | 0.0173 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1096 | 0.1159 | 0.5 |
Entamoeba histolytica | histone deacetylase, putative | 0.1096 | 0.1159 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0822 | 0.0739 | 0.0739 |
Echinococcus granulosus | histone deacetylase 6 | 0.0433 | 0.0142 | 0.0142 |
Trypanosoma brucei | histone deacetylase 3 | 0.0433 | 0.0142 | 0.1224 |
Echinococcus granulosus | histone deacetylase | 0.0433 | 0.0142 | 0.0142 |
Echinococcus multilocularis | histone deacetylase 3 | 0.1096 | 0.1159 | 0.1159 |
Schistosoma mansoni | Protein orai-1 | 0.6854 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0453 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.1096 | 0.1159 | 0.1159 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.1096 | 0.1159 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.1096 | 0.1159 | 0.1159 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1096 | 0.1159 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1517 | 0.1805 | 0.1805 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0433 | 0.0142 | 0.1224 |
Leishmania major | histone deacetylase, putative | 0.1096 | 0.1159 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.1096 | 0.1159 | 1 |
Schistosoma mansoni | histone deacetylase | 0.1096 | 0.1159 | 0.1159 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1096 | 0.1159 | 0.5 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.1096 | 0.1159 | 0.1159 |
Brugia malayi | Histone deacetylase family protein | 0.0433 | 0.0142 | 0.0142 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0433 | 0.0142 | 0.0142 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0341 | 0 | 0.5 |
Giardia lamblia | Histone deacetylase | 0.1096 | 0.1159 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1096 | 0.1159 | 0.5 |
Echinococcus multilocularis | histone deacetylase 1 | 0.1096 | 0.1159 | 0.1159 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0433 | 0.0142 | 0.0142 |
Brugia malayi | hypothetical protein | 0.1517 | 0.1805 | 0.1805 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1096 | 0.1159 | 0.5 |
Echinococcus granulosus | histone deacetylase 1 | 0.1096 | 0.1159 | 0.1159 |
Loa Loa (eye worm) | hypothetical protein | 0.6854 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0433 | 0.0142 | 0.0142 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.1096 | 0.1159 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0433 | 0.0142 | 0.0142 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.4 uM | Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS assay | ChEMBL. | 23628335 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23628335 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.