Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.4345 | 0.4345 |
Entamoeba histolytica | protein kinase, putative | 0.0186 | 0.1651 | 0.5 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0186 | 0.1651 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0186 | 0.1651 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.4345 | 0.4345 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0809 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0186 | 0.1651 | 0.5 |
Echinococcus multilocularis | kinesin protein KIF20A | 0.0501 | 0.587 | 0.587 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0186 | 0.1651 | 0.1651 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0186 | 0.1651 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1632 | 0.1632 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0063 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0809 | 1 | 1 |
Echinococcus granulosus | dual specificity | 0.0186 | 0.1651 | 0.1651 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0809 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0186 | 0.1651 | 0.1651 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0063 | 0 | 0.5 |
Echinococcus granulosus | kinesin protein KIF20A | 0.0501 | 0.587 | 0.587 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0063 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0387 | 0.4345 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0186 | 0.1651 | 0.5 |
Echinococcus granulosus | kinesin protein KIF20A | 0.0501 | 0.587 | 0.587 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0186 | 0.1651 | 1 |
Echinococcus multilocularis | dual specificity | 0.0186 | 0.1651 | 0.1651 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1632 | 0.1632 |
Giardia lamblia | Kinase, CMGC CLK | 0.0063 | 0 | 0.5 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0186 | 0.1651 | 1 |
Echinococcus multilocularis | kinesin protein KIF20A | 0.0501 | 0.587 | 0.587 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0063 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0186 | 0.1651 | 0.38 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 13.77 uM | Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTS assay | ChEMBL. | 23628335 |
IC50 (functional) | > 40.2 uM | Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS assay | ChEMBL. | 23628335 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23628335 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.