Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | 0.0654 | 0.4619 | 0.4619 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0654 | 0.4619 | 0.4619 |
Schistosoma mansoni | glycogen phosphorylase | 0.1382 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.1382 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0597 | 0.4204 | 0.4204 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0597 | 0.4204 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.1382 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.1382 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.1382 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.1382 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.1382 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.1382 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.1382 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.1382 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.1382 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.1382 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.1382 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.1382 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.1382 | 1 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0597 | 0.4204 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.1382 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 66 nM | Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis | ChEMBL. | 23618710 |
Ki (binding) | = 551 nM | Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis | ChEMBL. | 23618710 |
Ki (binding) | = 3544 nM | Displacement of [3H]U69,593 from human recombinant kappa opioid receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis | ChEMBL. | 23618710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.