Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | high affinity choline transporter 1 | 0.2819 | 0.2059 | 0.1992 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.2819 | 0.2059 | 0.1992 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.2819 | 0.2059 | 0.1992 |
Onchocerca volvulus | 0.2819 | 0.2059 | 0.5 | |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.2819 | 0.2059 | 0.5 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 1.1049 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 1.1049 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 1.1049 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2819 | 0.2059 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0749 | 0.0061 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.2819 | 0.2059 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 1.1049 | 1 | 1 |
Echinococcus granulosus | solute carrier family 5 | 1.1049 | 1 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 1.1049 | 1 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.2819 | 0.2059 | 0.1992 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 1.1049 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 1.1049 | 1 | 1 |
Brugia malayi | GH02984p | 0.2819 | 0.2059 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.2819 | 0.2059 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -53 % | Serum total cholesterol-lowering activity in the cholesterol-fed rats expressed as the ratio of the observed reduction to the difference between the control and normal levels 100 (0.3 mg/kg po) | ChEMBL. | 7636880 |
Change (functional) | = -53 % | Serum total cholesterol-lowering activity in the cholesterol-fed rats expressed as the ratio of the observed reduction to the difference between the control and normal levels 100. (0.3mg/kg, po) | ChEMBL. | 7636880 |
IC50 (binding) | = 0.064 uM | Inhibition of rabbit small-intestinal Acyl coenzyme A:cholesterol acyltransferase 1 | ChEMBL. | 7636880 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.