Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | transient receptor potential cation channel | 0.0198 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | thymidylate synthase | 0.1582 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1582 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1582 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.1582 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1582 | 1 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0198 | 0.0007 | 0.0007 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1582 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.0007 | 0.0007 |
Echinococcus multilocularis | thymidylate synthase | 0.1582 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1582 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1582 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1582 | 1 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0198 | 0.0007 | 0.0007 |
Brugia malayi | hypothetical protein | 0.0753 | 0.4011 | 0.4007 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1582 | 1 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0198 | 0.0007 | 0.0007 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0198 | 0.0007 | 0.0007 |
Onchocerca volvulus | 0.1582 | 1 | 0.5 | |
Schistosoma mansoni | transient receptor potential channel | 0.0198 | 0.0007 | 0.0007 |
Mycobacterium ulcerans | thymidylate synthase | 0.1582 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0753 | 0.4011 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1582 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.