Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 9 | Starlite/ChEMBL | References |
Homo sapiens | nicotinamide phosphoribosyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 490 aa | 441 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | bromodomain containing protein 7 | 0.053 | 0.3072 | 0.09 |
Schistosoma mansoni | bromodomain containing | 0.0546 | 0.317 | 1 |
Entamoeba histolytica | nicotinate phosphoribosyltransferase, putative | 0.0078 | 0.0307 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.053 | 0.3072 | 0.9658 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB1 | 0.0078 | 0.0307 | 0.5 |
Trichomonas vaginalis | nicotinate phosphoribosyltransferase, putative | 0.0078 | 0.0307 | 0.5 |
Echinococcus multilocularis | Bromodomain containing protein | 0.1664 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0546 | 0.317 | 1 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0418 | 0.2387 | 0.7265 |
Plasmodium falciparum | nicotinate phosphoribosyltransferase, putative | 0.0078 | 0.0307 | 0.5 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB2 | 0.0078 | 0.0307 | 0.5 |
Brugia malayi | Pre-B cell enhancing factor precursor | 0.0418 | 0.2387 | 0.753 |
Leishmania major | nicotinate phosphoribosyltransferase, putative | 0.0078 | 0.0307 | 0.5 |
Echinococcus granulosus | bromodomain containing protein 7 | 0.053 | 0.3072 | 0.09 |
Treponema pallidum | nicotinate phosphoribosyltransferase | 0.0078 | 0.0307 | 0.5 |
Trypanosoma brucei | nicotinate phosphoribosyltransferase, putative | 0.0078 | 0.0307 | 0.5 |
Trypanosoma cruzi | nicotinate phosphoribosyltransferase, putative | 0.0078 | 0.0307 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.317 | 1 |
Loa Loa (eye worm) | pre-B cell enhancing factor | 0.0418 | 0.2387 | 0.753 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 61 ml/min.kg | Hepatic clearance in CD-1 mouse liver microsomes at 1 uM after 20 to 60 mins by LC-MS/MS analysis | ChEMBL. | 23668988 |
IC50 (binding) | = 4 nM | Inhibition of NAMPT (unknown origin) assessed as NAM conversion to NMN preincubated for 15 mins prior to substrate addition measured after 30 mins by mass spectrophotometric analysis | ChEMBL. | 23668988 |
IC50 (functional) | = 42 nM | Antiproliferative activity against human A2780 cells after 72 hrs by sulforhodamine B assay | ChEMBL. | 23668988 |
IC50 (ADMET) | > 10000 nM | Inhibition of CYP2C9 in human liver microsomes after 30 mins | ChEMBL. | 23668988 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23668988 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.