Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Acetyl-coenzyme A transporter, putative | 0.2229 | 1 | 0.5 |
Brugia malayi | Protein C21B10.09 in chromosome II | 0.2229 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 33 | 0.2229 | 1 | 0.5 |
Plasmodium falciparum | acetyl-CoA transporter, putative | 0.2229 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2229 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 33 | 0.2229 | 1 | 0.5 |
Schistosoma mansoni | solute carrier family 33 (acetyl-CoA transporter | 0.2229 | 1 | 1 |
Schistosoma mansoni | solute carrier family 33 (acetyl-CoA transporter | 0.2229 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 16.8 nM | Binding affinity against adenosine A2A receptor in rat striatal membranes using [3H]-CGS- 21680. | ChEMBL. | 9703463 |
Ki (binding) | = 405 nM | Binding affinity against rat adenosine A3 receptor expressed in CHO cells using [125I]-. | ChEMBL. | 9703463 |
Ki (binding) | = 725 nM | Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]-R-PIA. | ChEMBL. | 9703463 |
Ratio (binding) | = 0.041 | Selectivity for binding affinity towards A2A adenosine receptor in rat striatal membrane and rat A3 receptor expressed in CHO cells. | ChEMBL. | 9703463 |
Ratio (binding) | = 1.7 | Selectivity for binding affinity towards A1 adenosine receptor in rat brain membrane and rat A3 receptor expressed in CHO cells. | ChEMBL. | 9703463 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.