Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0559 | 0.2036 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1275 | 0.5485 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0559 | 0.2036 | 0.1935 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0253 | 0.0559 | 0.0829 |
Giardia lamblia | DNA topoisomerase II | 0.0488 | 0.1691 | 1 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0163 | 0.0125 | 0.05 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0559 | 0.2036 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0253 | 0.0559 | 0.0439 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0396 | 0.1249 | 0.2097 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0163 | 0.0125 | 0.0615 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0396 | 0.1249 | 0.2097 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.1249 | 0.5359 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0656 | 0.2502 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0559 | 0.2036 | 0.1935 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0559 | 0.2036 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0396 | 0.1249 | 0.2097 |
Brugia malayi | Probable DNA topoisomerase II | 0.0559 | 0.2036 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1496 | 0.655 | 0.6507 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0559 | 0.2036 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0559 | 0.2036 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0253 | 0.0559 | 0.0439 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0163 | 0.0125 | 0.05 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0716 | 0.2789 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1275 | 0.5485 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0559 | 0.2036 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1275 | 0.5485 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.2212 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.2212 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.2212 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.2212 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0253 | 0.0559 | 0.0439 |
Leishmania major | DNA topoisomerase ii | 0.0396 | 0.1249 | 0.2097 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0559 | 0.2036 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0559 | 0.2036 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0253 | 0.0559 | 0.0439 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0559 | 0.2036 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0253 | 0.0559 | 0.0439 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0559 | 0.2036 | 0.8135 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0396 | 0.1249 | 0.2097 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.2212 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0253 | 0.0559 | 0.0439 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.1275 | 0.5485 | 1 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0163 | 0.0125 | 0.0615 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0559 | 0.2036 | 0.3651 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0163 | 0.0125 | 0.0615 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1123 | 0.5222 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0559 | 0.2036 | 1 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0163 | 0.0125 | 0.0615 |
Plasmodium falciparum | DNA gyrase subunit B | 0.2212 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1123 | 0.5222 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 58 % | Antituberculosis activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 250 ug/ml after 12 to 28 days by Lowenstein-Jensen method relative to control | ChEMBL. | 23747804 |
MIC (functional) | = 500 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition by broth microdilution method | ChEMBL. | 23747804 |
MIC (functional) | = 500 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition by broth microdilution method | ChEMBL. | 23747804 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.