Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0559 | 0.2036 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0396 | 0.1249 | 0.2097 |
Brugia malayi | Probable DNA topoisomerase II | 0.0559 | 0.2036 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1496 | 0.655 | 0.6507 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0656 | 0.2502 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0559 | 0.2036 | 0.1935 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0396 | 0.1249 | 0.2097 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.1249 | 0.5359 | 1 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0163 | 0.0125 | 0.0615 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0396 | 0.1249 | 0.2097 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0559 | 0.2036 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0253 | 0.0559 | 0.0439 |
Giardia lamblia | DNA topoisomerase II | 0.0488 | 0.1691 | 1 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0163 | 0.0125 | 0.05 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0559 | 0.2036 | 0.1935 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1275 | 0.5485 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0253 | 0.0559 | 0.0829 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0559 | 0.2036 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.2212 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1123 | 0.5222 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0163 | 0.0125 | 0.0615 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0559 | 0.2036 | 0.3651 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0163 | 0.0125 | 0.0615 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.1275 | 0.5485 | 1 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0163 | 0.0125 | 0.0615 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0559 | 0.2036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.1123 | 0.5222 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0396 | 0.1249 | 0.2097 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.2212 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0253 | 0.0559 | 0.0439 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0253 | 0.0559 | 0.0439 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.2212 | 1 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0396 | 0.1249 | 0.2097 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0559 | 0.2036 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0253 | 0.0559 | 0.0439 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0559 | 0.2036 | 0.8135 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0253 | 0.0559 | 0.0439 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0559 | 0.2036 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0559 | 0.2036 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1275 | 0.5485 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.2212 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.2212 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.2212 | 1 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0716 | 0.2789 | 1 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0163 | 0.0125 | 0.05 |
Schistosoma mansoni | DNA topoisomerase II | 0.0559 | 0.2036 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1275 | 0.5485 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0559 | 0.2036 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0253 | 0.0559 | 0.0439 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0559 | 0.2036 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 99 % | Antituberculosis activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 250 ug/ml after 12 to 28 days by Lowenstein-Jensen method relative to control | ChEMBL. | 23747804 |
MIC (functional) | = 25 ug ml-1 | Antituberculosis activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 12 to 28 days by Lowenstein-Jensen method | ChEMBL. | 23747804 |
MIC (functional) | = 125 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition by broth microdilution method | ChEMBL. | 23747804 |
MIC (functional) | = 500 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition by broth microdilution method | ChEMBL. | 23747804 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.