Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | DNA topoisomerase II, putative | 0.0673 | 0.1906 | 0.1906 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0673 | 0.1906 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.02 | 0.001 | 0.001 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.02 | 0.001 | 0.0038 |
Leishmania major | DNA topoisomerase ii | 0.0476 | 0.1113 | 0.205 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0673 | 0.1906 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0673 | 0.1906 | 0.3579 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1813 | 0.6473 | 0.6473 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0476 | 0.1113 | 0.205 |
Echinococcus granulosus | dihydrofolate reductase | 0.02 | 0.001 | 0.0054 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0476 | 0.1113 | 0.205 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.1526 | 0.5324 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0476 | 0.1113 | 0.205 |
Echinococcus multilocularis | dihydrofolate reductase | 0.02 | 0.001 | 0.0054 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0673 | 0.1906 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.026 | 0.0251 | 0.0251 |
Schistosoma mansoni | DNA topoisomerase II | 0.0673 | 0.1906 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.1553 | 0.5432 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0673 | 0.1906 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.026 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0673 | 0.1906 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.02 | 0.001 | 0.0054 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1553 | 0.5432 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.02 | 0.001 | 0.0054 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0673 | 0.1906 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.026 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.1005 | 0.5274 |
Brugia malayi | Dihydrofolate reductase | 0.02 | 0.001 | 0.0054 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.2693 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.2693 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.026 | 0.0251 | 0.0251 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0673 | 0.1906 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.1005 | 0.5274 |
Chlamydia trachomatis | dihydrofolate reductase | 0.02 | 0.001 | 0.001 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.026 | 0.0251 | 0.0472 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0673 | 0.1906 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.026 | 0.0251 | 0.0251 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0673 | 0.1906 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0673 | 0.1906 | 0.1906 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0476 | 0.1113 | 0.205 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.026 | 0.0251 | 0.0241 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.2693 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1553 | 0.5432 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.2693 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.2693 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.2693 | 1 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0673 | 0.1906 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.026 | 0.0251 | 0.0251 |
Giardia lamblia | DNA topoisomerase II | 0.0586 | 0.1558 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.02 | 0.001 | 0.0054 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.088 | 0.2735 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1553 | 0.5432 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0673 | 0.1906 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 99 % | Antituberculosis activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 250 ug/ml after 12 to 28 days by Lowenstein-Jensen method relative to control | ChEMBL. | 23747804 |
MIC (functional) | = 12.5 ug ml-1 | Antituberculosis activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 12 to 28 days by Lowenstein-Jensen method | ChEMBL. | 23747804 |
MIC (functional) | = 125 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition by broth microdilution method | ChEMBL. | 23747804 |
MIC (functional) | = 500 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition by broth microdilution method | ChEMBL. | 23747804 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.