Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2Y, G-protein coupled, 12 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0096 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0096 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0096 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0096 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0096 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0096 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0096 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0096 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0096 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor RXR | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0096 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0096 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0096 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0096 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0096 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0096 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0096 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0096 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0096 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0096 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0096 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0096 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0096 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0096 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0096 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0096 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0096 | 0.5 | 0.5 | |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0096 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0096 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0096 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0096 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0096 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0096 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.12 uM | Antagonist activity at P2Y12 receptor in human washed platelets assessed as inhibition of fibrinogen-induced aggregation | ChEMBL. | 23747805 |
IC50 (binding) | = 0.17 uM | Displacement of [125I]-AZ11931285 from P2Y12 receptor (unknown origin) after 1 hr by scintillation counting analysis | ChEMBL. | 23747805 |
IC50 (functional) | = 0.22 uM | Antagonist activity at P2Y12 receptor (unknown origin) assessed as inhibition of GTPgammaS binding after 1 hr by scintillation counting analysis | ChEMBL. | 23747805 |
Papp (ADMET) | = 0.6 ucm/s | Apparent Permeability across apical to basolateral side in human Caco2 cells at 1 to 10 uM measured at 30 to 90 mins by LC/MS analysis | ChEMBL. | 23747805 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.