Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0189979 | 0.5 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0189979 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0782 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0189979 | 0.5 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0782 | 0.5 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0782 | 0.5 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0189979 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0189979 | 0.5 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0189979 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0189979 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0782 | 0.5 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0189979 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0189979 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0189979 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0189979 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0782 | 0.5 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0782 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0189979 | 0.5 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0189979 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0782 | 0.5 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0782 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0189979 | 0.5 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0189979 | 0.5 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.0189979 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0782 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0782 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0782 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0189979 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0782 | 0.5 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0782 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0782 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0782 | 0.5 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0782 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 15.015 uM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in O-positive erythrocytes assessed as parasite growth inhibition after 72 hrs by DNA staining-based assay | ChEMBL. | 23747806 |
EC50 (ADMET) | = 26.0417 uM | Cytotoxicity against human BJ cells after 72 hrs by celltiter-glo assay | ChEMBL. | 23747806 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 23747806 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.