Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ORAI calcium release-activated calcium modulator 1 | References | |
Homo sapiens | ORAI calcium release-activated calcium modulator 3 | Starlite/ChEMBL | References |
Homo sapiens | ORAI calcium release-activated calcium modulator 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | Protein orai-1 | Get druggable targets OG5_130743 | All targets in OG5_130743 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_130743 | All targets in OG5_130743 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130743 | All targets in OG5_130743 |
Schistosoma mansoni | Protein orai-1 | Get druggable targets OG5_130743 | All targets in OG5_130743 |
Schistosoma japonicum | IPR012446,Protein of unknown function DUF1650,domain-containing | Get druggable targets OG5_130743 | All targets in OG5_130743 |
Echinococcus granulosus | calcium release activated calcium channel | Get druggable targets OG5_130743 | All targets in OG5_130743 |
Echinococcus multilocularis | calcium release activated calcium channel | Get druggable targets OG5_130743 | All targets in OG5_130743 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0104 | 0.0019 | 0.0019 |
Echinococcus granulosus | integrin beta 2 | 0.0505 | 0.3303 | 0.2729 |
Schistosoma mansoni | integrin beta subunit | 0.0401 | 0.2456 | 0.228 |
Echinococcus multilocularis | integrin beta 2 | 0.0505 | 0.3303 | 0.2729 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0198 | 0.079 | 0.0772 |
Echinococcus granulosus | calcium release activated calcium channel | 0.1323 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.079 | 0.079 |
Schistosoma mansoni | Protein orai-1 | 0.1323 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0228 | 0.0228 |
Onchocerca volvulus | Putative nachr subunit | 0.0198 | 0.079 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0585 | 0.396 | 0.396 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.1323 | 1 | 1 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.1323 | 1 | 1 |
Brugia malayi | Cation transporter family protein | 0.0129 | 0.0228 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0228 | 0.0228 |
Schistosoma mansoni | Protein orai-1 | 0.1323 | 1 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0585 | 0.396 | 0.3948 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0198 | 0.079 | 0.079 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.8 uM | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Cd2+ influx after 10 mins by FLIPR assay in presence of thapsigargin | ChEMBL. | 23602525 |
IC50 (binding) | = 20.2 uM | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Cd2+ influx after 5 mins by FLIPR assay | ChEMBL. | 23602525 |
IC50 (binding) | = 36.6 uM | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Ca2+ influx after 5 mins by FLIPR assay | ChEMBL. | 23602525 |
IC50 (binding) | = 40.5 uM | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Ca2+ influx after 10 mins by FLIPR assay in presence of thapsigargin | ChEMBL. | 23602525 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.