Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | pyruvate kinase | 0.1674 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.1674 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.1674 | 1 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.1674 | 1 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.1674 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.1674 | 1 | 0.5 |
Giardia lamblia | Pyruvate kinase | 0.1674 | 1 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.1167 | 0.5661 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.1674 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.1674 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.1674 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.1674 | 1 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.1674 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.1674 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.1674 | 1 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.1674 | 1 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.1674 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.1674 | 1 | 0.5 |
Mycobacterium ulcerans | pyruvate kinase | 0.1674 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.1674 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.1674 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.1674 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.1321 | 0.6979 | 0.5671 |
Plasmodium vivax | pyruvate kinase, putative | 0.1674 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.1674 | 1 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1 | 0.1674 | 1 | 0.5 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.1674 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.1674 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1674 | 1 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.1674 | 1 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.1674 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.1674 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production | ChEMBL. | 23623258 | |
Ki (binding) | Displacement of [3H]-CP-55,940 from human CB1 receptor expressed in CHO cell membranes | ChEMBL. | 23623258 | |
Ki (binding) | = 204 nM | Displacement of [3H]-CP-55,940 from human CB2 receptor expressed in CHO cell membranes | ChEMBL. | 23623258 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.