Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0742 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0742 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0377 | 0.0432 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0377 | 0.0432 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0742 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0377 | 0.0432 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0377 | 0.0432 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0742 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0377 | 0.0432 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0377 | 0.0432 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 50 % | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL6 release at 10 uM incubated for 2 hrs prior to LPS challenge measured after 22 hrs by ELISA relative to LPS-treated control | ChEMBL. | 23644212 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.