Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.075 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0381 | 0.0432 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.075 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0381 | 0.0432 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.075 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0381 | 0.0432 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0381 | 0.0432 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0381 | 0.0432 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.075 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0381 | 0.0432 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 300 uM | Displacement of biotinylated fibrinogen from human glycoprotein 2b/3a receptor after 2 hrs by chemiluminescence assay | ChEMBL. | 23644213 |
Ki (binding) | = 49.3 uM | Inhibition of F10a (unknown origin) using S-2222 as substrate incubated for 15 mins prior to substrate addition measured every 10 secs by spectrophotometric analysis | ChEMBL. | 23644213 |
Ki (binding) | > 100 uM | Inhibition of trypsin (unknown origin) using S-2222 as substrate incubated for 15 mins prior to substrate addition measured every 10 secs by spectrophotometric analysis | ChEMBL. | 23644213 |
Ki (binding) | > 100 uM | Inhibition of thrombin (unknown origin) using S-2238 as substrate incubated for 15 mins prior to substrate addition measured every 10 secs by spectrophotometric analysis | ChEMBL. | 23644213 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.