Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0604 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0659 | 1 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0659 | 1 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.0659 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | > 50 % | Inhibition of human recombinant GSK3beta using pIRS-1 (RREGGMSRPAS(p)VDG) as substrate assessed as residual activity at 10 uM after 15 mins in presence of 32P[gamma-ATP] | ChEMBL. | 22749643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.