Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0095 | 0.1084 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0351 | 0.7339 | 0.7255 |
Brugia malayi | hypoxia-induced factor 1 | 0.0157 | 0.2586 | 0.2586 |
Toxoplasma gondii | hypothetical protein | 0.0095 | 0.1084 | 1 |
Onchocerca volvulus | 0.0051 | 0.0021 | 0.5 | |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.046 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0095 | 0.1084 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0093 | 0.0093 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0095 | 0.1084 | 1 |
Plasmodium falciparum | protease, putative | 0.0095 | 0.1084 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0095 | 0.1084 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0093 | 0.0073 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0123 | 0.1758 | 0.1498 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0064 | 0.0319 | 0.0319 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0157 | 0.2586 | 0.2571 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0064 | 0.0319 | 0.0166 |
Plasmodium vivax | protease, putative | 0.0095 | 0.1084 | 0.5 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.046 | 1 | 0.5 |
Chlamydia trachomatis | hypothetical protein | 0.0095 | 0.1084 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.0123 | 0.0103 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.046 | 1 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0123 | 0.1758 | 0.1498 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 0.0319 | 0.0013 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0306 | 0.0306 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0306 | 0.0306 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.046 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0086 | 0.0858 | 0.0858 |
Treponema pallidum | hypothetical protein | 0.0095 | 0.1084 | 0.5 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0095 | 0.1084 | 1 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.046 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.0319 | 0.0166 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0064 | 0.0319 | 0.0013 |
Mycobacterium ulcerans | integral membrane protein | 0.0095 | 0.1084 | 1 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0064 | 0.0319 | 0.0319 |
Schistosoma mansoni | lipoxygenase | 0.0123 | 0.1758 | 0.1758 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0095 | 0.1084 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.0319 | 0.0166 |
Entamoeba histolytica | CAAX prenyl protease family | 0.046 | 1 | 1 |
Toxoplasma gondii | CAAX amino terminal protease family protein | 0.0095 | 0.1084 | 1 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.046 | 1 | 1 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.046 | 1 | 0.5 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.046 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.046 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.017 | 0.2907 | 0.2907 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 0.0319 | 0.0013 |
Mycobacterium tuberculosis | Probable integral membrane protein | 0.0095 | 0.1084 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.2907 | 0.2892 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.046 | 1 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.0021 | 0.0021 |
Echinococcus granulosus | tumor protein p63 | 0.0351 | 0.7339 | 0.7255 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.29 uM | Cytotoxicity against human HepG2 cells assessed as cell survival after 48 hrs by SRB assay | ChEMBL. | 23708013 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23708013 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.