Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | aminopeptidase, putative | 0.0068 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0068 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0068 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0068 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0068 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5828 | 0.683 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.8533 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0068 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0231 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0068 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0231 | 1 | 1 |
Onchocerca volvulus | 0.0231 | 1 | 1 | |
Entamoeba histolytica | aminopeptidase, putative | 0.0068 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0068 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0068 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0068 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0187 | 0.7295 | 0.8549 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0068 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 120.1 ug ml-1 | Antibacterial activity against Escherichia coli assessed as survival after 24 hrs by MTT assay | ChEMBL. | 23770447 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.