Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aminopeptidase N | 0.099 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0291 | 0 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0291 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0887 | 0.8533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0698 | 0.5828 | 0.683 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0291 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0291 | 0 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0291 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0291 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0291 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0291 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0291 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0291 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0291 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0801 | 0.7295 | 0.8549 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0291 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0291 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.099 | 1 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0291 | 0 | 0.5 |
Onchocerca volvulus | 0.099 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (ADMET) | > 50 uM | Cytotoxicity against human WI38 cells assessed as growth inhibition after 48 hrs by MTS assay | ChEMBL. | 23795241 |
Ki (binding) | > 50 uM | Inhibition of wild type IDH1 (unknown origin) expressed in Escherichia coli BL21 using alpha-ketoglutarate as substrate incubated for 5 mins prior to substrate addition measured every 30 secs | ChEMBL. | 23795241 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.