Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | elastase, neutrophil expressed | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | transmembrane protease serine 3 | elastase, neutrophil expressed | 267 aa | 236 aa | 27.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0022 | 0.0077 | 0.1145 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0015 | 0.0023 | 0.043 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0015 | 0.0023 | 0.043 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1306 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0015 | 0.0023 | 0.043 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.007 | 0.045 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1306 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0022 | 0.0077 | 0.1145 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0015 | 0.0023 | 0.043 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0022 | 0.0077 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.007 | 0.045 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0015 | 0.0023 | 0.043 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0015 | 0.0023 | 0.043 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0075 | 0.0488 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0022 | 0.0077 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0082 | 0.0541 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.0077 | 0.1414 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0077 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0412 | 0.0389 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0075 | 0.0488 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0075 | 0.0488 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0022 | 0.0077 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.1306 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0082 | 0.0541 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0075 | 0.0488 | 0.0466 |
Toxoplasma gondii | hypothetical protein | 0.1306 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.0077 | 0.1414 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | Percent inhibition of elastase-induced lung damage by 10 mg/kg dosed orally, 30 minutes prior to the instillation of 50 ug of elastase | ChEMBL. | 9379436 |
Ki (binding) | = 1.1 nM | Binding affinity for human leukocyte elastase | ChEMBL. | 9379436 |
Ki (binding) | = 1.1 nM | Binding affinity for human leukocyte elastase | ChEMBL. | 9379436 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.