Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ORAI calcium release-activated calcium modulator 1 | References | |
Homo sapiens | transient receptor potential cation channel, subfamily V, member 6 | Starlite/ChEMBL | References |
Homo sapiens | ORAI calcium release-activated calcium modulator 2 | Starlite/ChEMBL | References |
Homo sapiens | ORAI calcium release-activated calcium modulator 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | TRP channel protein nanchung | transient receptor potential cation channel, subfamily V, member 6 | 725 aa | 595 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | calcium release activated calcium channel | 0.1323 | 1 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0027 | 0.0128 | 0.0128 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0128 | 0.09 | 0.09 |
Trypanosoma cruzi | extracellular receptor, putative | 0.001 | 0 | 0.5 |
Schistosoma mansoni | Protein orai-1 | 0.1323 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0041 | 0.0237 | 0.0237 |
Loa Loa (eye worm) | glutamate receptor | 0.0104 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.1323 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0054 | 0.0054 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0128 | 0.09 | 0.09 |
Entamoeba histolytica | hypothetical protein | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.09 | 0.09 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0128 | 0.0128 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0094 | 0.0643 | 0.0643 |
Leishmania major | extracellular receptor, putative | 0.001 | 0 | 0.5 |
Brugia malayi | olfactory channel protein osm-9 | 0.0093 | 0.0636 | 0.0636 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0087 | 0.0589 | 0.0589 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0027 | 0.0128 | 0.0128 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0087 | 0.0589 | 0.0589 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0051 | 0.0311 | 0.0311 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0017 | 0.0054 | 1 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0017 | 0.0054 | 0.0054 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0017 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0636 | 0.0636 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0027 | 0.0128 | 0.0128 |
Echinococcus granulosus | calcium release activated calcium channel | 0.1323 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0051 | 0.0311 | 0.0311 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0118 | 0.0826 | 0.0826 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0104 | 0.0717 | 0.0717 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0017 | 0.0054 | 1 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0017 | 0.0054 | 0.0054 |
Schistosoma mansoni | Protein orai-1 | 0.1323 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0087 | 0.0589 | 0.0589 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.4 uM | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Cd2+ influx after 10 mins by FLIPR assay in presence of thapsigargin | ChEMBL. | 23602525 |
IC50 (binding) | = 9.7 uM | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Ca2+ influx after 5 mins by FLIPR assay | ChEMBL. | 23602525 |
IC50 (binding) | = 12 uM | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Cd2+ influx after 5 mins by FLIPR assay | ChEMBL. | 23602525 |
IC50 (binding) | = 21.8 uM | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Ca2+ influx after 10 mins by FLIPR assay in presence of thapsigargin | ChEMBL. | 23602525 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.