Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.002 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0033 | 0.1763 | 0.5 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0095 | 1 | 0.5 |
Mycobacterium ulcerans | integral membrane protein | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0095 | 1 | 0.5 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0095 | 1 | 1 |
Plasmodium vivax | protease, putative | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0095 | 1 | 1 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0095 | 1 | 0.5 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0095 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.002 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.002 | 0 | 0.5 |
Toxoplasma gondii | CAAX amino terminal protease family protein | 0.002 | 0 | 0.5 |
Plasmodium falciparum | protease, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0095 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0095 | 1 | 0.5 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0095 | 1 | 1 |
Chlamydia trachomatis | hypothetical protein | 0.002 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.002 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0 | 0.5 |
Treponema pallidum | hypothetical protein | 0.002 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0095 | 1 | 1 |
Mycobacterium tuberculosis | Probable integral membrane protein | 0.002 | 0 | 0.5 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0095 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 8 mm | Antibacterial activity against Escherichia coli ATCC 35218 assessed as growth inhibition at 10 ug/ml by disc diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.