Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hint module family protein | 0.0157 | 0 | 0.5 |
Echinococcus multilocularis | smoothened | 0.071 | 1 | 1 |
Brugia malayi | Hint module family protein | 0.0157 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0695 | 0.9735 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0421 | 0.4779 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 6 mm | Antibacterial activity against Escherichia coli ATCC 8739 at 50 ug/ml after 24 hrs by agar well diffusion method | ChEMBL. | No reference |
IZ (functional) | = 10 mm | Antibacterial activity against Escherichia coli ATCC 8739 at 100 ug/ml after 24 hrs by agar well diffusion method | ChEMBL. | No reference |
IZ (functional) | = 13 mm | Antibacterial activity against Escherichia coli ATCC 8739 at 200 ug/ml after 24 hrs by agar well diffusion method | ChEMBL. | No reference |
IZ (functional) | = 16 mm | Antibacterial activity against Escherichia coli ATCC 8739 at 300 ug/ml after 24 hrs by agar well diffusion method | ChEMBL. | No reference |
IZ (functional) | = 26 mm | Antibacterial activity against Escherichia coli ATCC 8739 at 500 ug/ml after 24 hrs by agar well diffusion method | ChEMBL. | No reference |
MIC (functional) | = 15 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 8739 after 24 hrs by agar well diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.