Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Wolbachia sp. subsp. Brugia malayi (strain TRS) | Delta-aminolevulinic acid dehydratase | Starlite/ChEMBL | References |
Pisum sativum | Delta-aminolevulinic acid dehydratase, chloroplastic | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | parasite porphobilinogen synthase PBGS | 0.0517 | 0.3113 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | delta-aminolevulinic acid dehydratase | 0.0517 | 0.3113 | 0.5 |
Chlamydia trachomatis | delta-aminolevulinic acid dehydratase | 0.0517 | 0.3113 | 0.5 |
Plasmodium vivax | delta-aminolevulinic acid dehydratase, putative | 0.0517 | 0.3113 | 0.5 |
Plasmodium falciparum | porphobilinogen synthase | 0.0517 | 0.3113 | 0.5 |
Mycobacterium leprae | PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH) | 0.0517 | 0.3113 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.1078 | 1 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1078 | 1 | 0.5 |
Schistosoma mansoni | sphingosine kinase A B | 0.1078 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.1078 | 1 | 1 |
Echinococcus multilocularis | sphingosine kinase 1 | 0.1078 | 1 | 1 |
Schistosoma mansoni | sphingoid long chain base kinase | 0.1078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1078 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 20 % | Stimulation of Pseudomonas aeruginosa PAO1 recombinant PBGS | ChEMBL. | 24568185 |
EC50 (binding) | = 60 uM | Stimulation of Escherichia coli recombinant PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
EC50 (binding) | = 66 uM | Stimulation of Yersinia enterocolitica recombinant PBGS expressed in Escherichia coli using 5-ALA as substrate | ChEMBL. | 24568185 |
EC50 (binding) | = 69 uM | Stimulation of Pseudomonas aeruginosa PAO1 recombinant PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
EC50 (binding) | = 182 uM | Stimulation of Vibrio cholerae recombinant PBGS expressed in Escherichia coli using 5-ALA as substrate | ChEMBL. | 24568185 |
FC (binding) | = 2.2 | Inhibition of Pisum sativum PBGS using 5-ALA as substrate assessed as decrease in affinity for Mg2+ at 100 uM relative to control | ChEMBL. | 24568185 |
FC (binding) | = 18.6 | Inhibition of C-terminal His-tagged Wolbachia PBGS using 5-ALA as substrate assessed as decrease in affinity for Mg2+ at 100 uM relative to control | ChEMBL. | 24568185 |
IC50 (binding) | = 10.6 uM | Inhibition of Pisum sativum PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
IC50 (binding) | = 11.1 uM | Inhibition of C-terminal His-tagged Wolbachia PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
IC50 (binding) | = 79 uM | Inhibition of Pseudomonas aeruginosa PAO1 recombinant PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
IC50 (binding) | = 739 uM | Inhibition of human PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
IC50 (binding) | = 740 uM | Inhibition of human ALADH after 20 mins | ChEMBL. | 24012123 |
IC50 (binding) | = 1111 uM | Inhibition of Drosophila melanogaster recombinant PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
Inhibition (binding) | Non-competitive inhibition of Pisum sativum PBGS using 5-ALA as substrate at 6.25 to 100 uM | ChEMBL. | 24568185 | |
Inhibition (binding) | Inhibition of Pisum sativum PBGS using 5-ALA as substrate at 8 to 2000 uM after 30 mins by nondenaturing PAGE analysis | ChEMBL. | 24568185 | |
Inhibition (binding) | Partial competitive inhibition of Pisum sativum PBGS using 5-ALA as substrate at 6.25 to 100 uM in presence of MgCl2 | ChEMBL. | 24568185 | |
Inhibition (binding) | Inhibition of C-terminal His-tagged Wolbachia PBGS using 5-ALA as substrate assessed as induction of inactive dimeric form at 25 to 2500 uM by nondenaturing PAGE analysis | ChEMBL. | 24568185 | |
Inhibition (binding) | Competitive inhibition of Pisum sativum PBGS using 5-ALA as substrate at 6.25 to 100 uM | ChEMBL. | 24568185 | |
Inhibition (binding) | Inhibition of C-terminal His-tagged Wolbachia PBGS using 5-ALA as substrate assessed as stabilization of inactive hexameric form at 25 to 2500 uM by nondenaturing PAGE analysis | ChEMBL. | 24568185 | |
Inhibition (binding) | Inhibition of C-terminal His-tagged Wolbachia PBGS using 5-ALA as substrate assessed as inhibition of octamer-inducing effect of 5-ALA at 25 to 2500 uM by nondenaturing PAGE analysis | ChEMBL. | 24568185 | |
Inhibition (binding) | Inhibition of Pisum sativum PBGS using 10 mM 5-ALA as substrate assessed as decrease in enzyme activity at 6.25 to 100 uM in presence of MgCl2 | ChEMBL. | 24568185 | |
Inhibition (binding) | Inhibition of C-terminal His-tagged Wolbachia PBGS using 5-ALA as substrate assessed as stabilization of inactive tetrameric form at 25 to 2500 uM by nondenaturing PAGE analysis | ChEMBL. | 24568185 | |
Smax (binding) | = 120.5 % | Stimulation of Escherichia coli recombinant PBGS using 5-ALA as substrate relative to control | ChEMBL. | 24568185 |
Smax (binding) | = 122.8 % | Stimulation of Pseudomonas aeruginosa PAO1 recombinant PBGS using 5-ALA as substrate relative to control | ChEMBL. | 24568185 |
Smax (binding) | = 151.7 % | Stimulation of Yersinia enterocolitica recombinant PBGS expressed in Escherichia coli using 5-ALA as substrate relative to control | ChEMBL. | 24568185 |
Smax (binding) | = 160 % | Stimulation of Vibrio cholerae recombinant PBGS expressed in Escherichia coli using 5-ALA as substrate relative to control | ChEMBL. | 24568185 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.