Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.059 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.1621 | 0.7295 | 0.8549 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.059 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.059 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.059 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.059 | 0 | 0.5 |
Onchocerca volvulus | 0.2003 | 1 | 1 | |
Entamoeba histolytica | aminopeptidase, putative | 0.059 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.2003 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.059 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.2003 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1413 | 0.5828 | 0.683 |
Loa Loa (eye worm) | hypothetical protein | 0.1796 | 0.8533 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.059 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.059 | 0 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.059 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.059 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.059 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.059 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | Antimicrobial activity against benznidazole-resistant epimastigotes of Trypanosoma cruzi Tulahuen 2 assessed as growth inhibition at 25 uM measured on day 5 by spectrophotometry | ChEMBL. | No reference | |
MIC (functional) | = 15.36 ug ml-1 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate Alamar Blue assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.