Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Nitric-oxide synthase, brain | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0027 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0027 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0027 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0013 | 0 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0027 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0027 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0017 | 0.2407 | 0.2407 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0014 | 0.0151 | 0.0151 |
Leishmania major | p450 reductase, putative | 0.0027 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0027 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0027 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0027 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0027 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0027 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0027 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0027 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0027 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0017 | 0.2407 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0024 | 0.7743 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0027 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0027 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0027 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0024 | 0.7743 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0027 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0027 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0027 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1599 nM | Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate up to 180 seconds by hemoglobin capture assay | ChEMBL. | 23993333 |
Ki (binding) | = 53222 nM | Inhibition of mouse recombinant iNOS expressed in Escherichia coli using L-arginine as substrate up to 180 seconds by hemoglobin capture assay | ChEMBL. | 23993333 |
Ki (binding) | = 92756 nM | Inhibition of bovine recombinant eNOS expressed in Escherichia coli using L-arginine as substrate up to 180 seconds by hemoglobin capture assay | ChEMBL. | 23993333 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.