Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Bos taurus | Nitric-oxide synthase, endothelial | Starlite/ChEMBL | References |
Rattus norvegicus | Nitric-oxide synthase, brain | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.034 | 0.1114 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.1491 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1491 | 0.4887 |
Trypanosoma cruzi | p450 reductase, putative | 0.0091 | 0.3051 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0081 | 0.254 | 0.8159 |
Brugia malayi | flavodoxin family protein | 0.0035 | 0.0277 | 0.0321 |
Echinococcus granulosus | methionine synthase reductase | 0.0056 | 0.1332 | 0.4367 |
Chlamydia trachomatis | sulfite reductase | 0.0056 | 0.1332 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0091 | 0.3051 | 0.3543 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0081 | 0.254 | 0.2328 |
Brugia malayi | hypothetical protein | 0.0036 | 0.034 | 0.0395 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.3051 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0091 | 0.3051 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.034 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0081 | 0.254 | 0.8326 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.034 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0091 | 0.3051 | 0.2853 |
Trichomonas vaginalis | set domain proteins, putative | 0.0233 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.034 | 0.1114 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.3051 | 0.3543 |
Treponema pallidum | flavodoxin | 0.0035 | 0.0277 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1491 | 0.4887 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.034 | 0.1114 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0081 | 0.254 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.3051 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1491 | 0.4887 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.3051 | 1 |
Brugia malayi | flavodoxin family protein | 0.0091 | 0.3051 | 0.3543 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.034 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1491 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0091 | 0.3051 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0091 | 0.3051 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.034 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0056 | 0.1332 | 0.1547 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.3051 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.3051 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0091 | 0.3051 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.3051 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0045 | 0.0787 | 0.5281 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.034 | 0.1114 |
Brugia malayi | Cytochrome P450 family protein | 0.0071 | 0.2066 | 0.24 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0091 | 0.3051 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0046 | 0.0822 | 0.2693 |
Brugia malayi | FAD binding domain containing protein | 0.0056 | 0.1332 | 0.1547 |
Brugia malayi | FAD binding domain containing protein | 0.0091 | 0.3051 | 0.3543 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0045 | 0.0787 | 0.2581 |
Echinococcus multilocularis | methionine synthase reductase | 0.0056 | 0.1332 | 0.4367 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1491 | 0.4378 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0056 | 0.1332 | 0.4367 |
Leishmania major | p450 reductase, putative | 0.0091 | 0.3051 | 1 |
Giardia lamblia | Hypothetical protein | 0.0081 | 0.254 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0091 | 0.3051 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.8611 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.8611 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0091 | 0.3051 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.3051 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.3051 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0035 | 0.0277 | 0.0321 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0277 | 0.0907 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1491 | 0.4887 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0091 | 0.3051 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0045 | 0.0787 | 0.5281 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0071 | 0.2066 | 0.24 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 47 nM | Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate up to 180 seconds by hemoglobin capture assay | ChEMBL. | 23993333 |
Ki (binding) | = 1857 nM | Inhibition of mouse recombinant iNOS expressed in Escherichia coli using L-arginine as substrate up to 180 seconds by hemoglobin capture assay | ChEMBL. | 23993333 |
Ki (binding) | = 2995 nM | Inhibition of bovine recombinant eNOS expressed in Escherichia coli using L-arginine as substrate up to 180 seconds by hemoglobin capture assay | ChEMBL. | 23993333 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.