Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.016 | 0.3163 | 0.3163 |
Echinococcus granulosus | bromodomain containing 2 | 0.0258 | 1 | 0.5 |
Entamoeba histolytica | bromodomain-containing protein | 0.0115 | 0 | 0.5 |
Giardia lamblia | Kinase, putative | 0.0115 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0258 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0143 | 0.1964 | 0.1964 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.016 | 0.3163 | 0.3163 |
Toxoplasma gondii | bromodomain-containing protein | 0.0115 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.016 | 0.3163 | 0.3163 |
Trichomonas vaginalis | conserved hypothetical protein | 0.016 | 0.3163 | 0.3163 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.016 | 0.3163 | 0.3163 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 1 | 1 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.0258 | 1 | 0.5 |
Entamoeba histolytica | bromodomain-containing protein | 0.0115 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0258 | 1 | 1 |
Entamoeba histolytica | bromodomain-containing protein | 0.0115 | 0 | 0.5 |
Onchocerca volvulus | 0.0115 | 0 | 0.5 | |
Echinococcus multilocularis | bromodomain containing 2 | 0.0258 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0258 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 | Binding affinity to His6-tagged BRD4 (unknown origin) after 60 mins by fluorescence anisotropy binding Assay | ChEMBL. | 24015967 |
IC50 (binding) | = 4 | Binding affinity to His6-tagged BRD3 (unknown origin) after 60 mins by fluorescence anisotropy binding Assay | ChEMBL. | 24015967 |
IC50 (binding) | = 4 | Binding affinity to His6-tagged BRD2 (unknown origin) after 60 mins by fluorescence anisotropy binding Assay | ChEMBL. | 24015967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.