Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 13 % | Agonist activity at rat TRPV1 expressed in CHO cells assessed as stimulation of Ca2+ uptake relative to capsaicin | ChEMBL. | 23981530 |
Activity (binding) | = 28 % | Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-stimulated Ca2+ uptake relative to control | ChEMBL. | 23981530 |
Activity (binding) | = 52 % | Agonist activity at human TRPV1 expressed in CHO cells assessed as stimulation of Ca2+ uptake relative to capsaicin | ChEMBL. | 23981530 |
Activity (binding) | = 75 % | Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-stimulated Ca2+ uptake relative to control | ChEMBL. | 23981530 |
EC50 (binding) | = 183 nM | Agonist activity at human TRPV1 expressed in CHO cells assessed as stimulation of Ca2+ uptake | ChEMBL. | 23981530 |
Ki (binding) | = 1.64 nM | Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells | ChEMBL. | 23981530 |
Ki (binding) | = 21.3 nM | Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-stimulated Ca2+ uptake | ChEMBL. | 23981530 |
Ki (binding) | = 50 nM | Displacement of [3H]RTX from human TRPV1 expressed in CHO cells | ChEMBL. | 23981530 |
Ki (binding) | = 451 nM | Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-stimulated Ca2+ uptake | ChEMBL. | 23981530 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.