Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | methionyl aminopeptidase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0925 | 0.1313 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0925 | 0.1313 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.1721 | 0.1721 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.312 | 0.312 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0053 | 0.3658 | 0.5 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0053 | 0.3658 | 0.5 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0053 | 0.3658 | 0.5194 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0053 | 0.3658 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.312 | 0.6667 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.314 | 0.6709 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.312 | 0.6667 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0742 | 0.1054 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0053 | 0.3658 | 0.3658 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0053 | 0.3658 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.7041 | 1 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0053 | 0.3658 | 0.5 |
Brugia malayi | initiation factor 2-associated protein. | 0.0053 | 0.3658 | 0.3658 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0742 | 0.1586 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0053 | 0.3658 | 0.5 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0053 | 0.3658 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0053 | 0.3658 | 0.5 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0053 | 0.3658 | 0.3658 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0053 | 0.3658 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0925 | 0.0925 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.1721 | 0.1721 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0053 | 0.3658 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.312 | 0.312 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.468 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0925 | 0.0925 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 1 | 1 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0053 | 0.3658 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0925 | 0.1976 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0053 | 0.3658 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0053 | 0.3658 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0742 | 0.0742 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0053 | 0.3658 | 0.7815 |
Giardia lamblia | Methionine aminopeptidase | 0.0053 | 0.3658 | 1 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0053 | 0.3658 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | > 98 % | In vitro anti-proliferative activity against human umbilical vein endothelial cells at 5 uM. | ChEMBL. | 15149671 |
GI (functional) | > 98 % | In vitro anti-proliferative activity against human umbilical vein endothelial cells at 5 uM. | ChEMBL. | 15149671 |
GI50 (functional) | = 1.8 uM | Anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) | ChEMBL. | 15149671 |
GI50 (functional) | = 1.8 uM | Anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) | ChEMBL. | 15149671 |
IC50 (binding) | = 169 nM | In vitro inhibition of human recombinant Methionine aminopeptidase 2. | ChEMBL. | 15149671 |
IC50 (binding) | = 169 nM | In vitro inhibition of human recombinant Methionine aminopeptidase 2. | ChEMBL. | 15149671 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.