Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0167 | 0.6675 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.3094 | 0.306 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0098 | 0.3094 | 0.3205 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0167 | 0.6675 | 0.6873 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0167 | 0.6675 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.2964 | 0.0658 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0202 | 0.0209 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.2964 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2202 | 0.2116 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0202 | 0.5 |
Brugia malayi | hypothetical protein | 0.0086 | 0.2499 | 0.243 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0167 | 0.6675 | 0.6913 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0202 | 0.0209 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.6749 | 0.6951 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.6749 | 0.6951 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0691 | 0.0518 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0167 | 0.6675 | 0.6913 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.014 | 0.5269 | 0.5457 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0224 | 0.9656 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0167 | 0.6675 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0224 | 0.9656 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0593 | 0.0414 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0202 | 0.0082 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0593 | 0.0414 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0098 | 0.3094 | 0.3205 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0098 | 0.3094 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0202 | 0.0209 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.3173 | 0.3199 |
Echinococcus multilocularis | geminin | 0.0168 | 0.6749 | 0.699 |
Echinococcus granulosus | expressed conserved protein | 0.0092 | 0.2787 | 0.2887 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0224 | 0.9656 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2499 | 0.243 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0224 | 0.9656 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0202 | 0.0209 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0224 | 0.9656 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0098 | 0.3094 | 0.306 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0509 | 0.0527 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0224 | 0.9656 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.2964 | 0.0658 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.2964 | 0.0658 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.014 | 0.5269 | 0.5457 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0167 | 0.6675 | 0.6847 |
Echinococcus granulosus | geminin | 0.0168 | 0.6749 | 0.699 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0113 | 0.3879 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0167 | 0.6675 | 0.5 |
Echinococcus multilocularis | expressed conserved protein | 0.0092 | 0.2787 | 0.2887 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0593 | 0.0414 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0593 | 0.0414 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0167 | 0.6675 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 31.8 uM | Cytotoxicity against human HL60 cells after 48 hrs by SRB assay | ChEMBL. | 24113365 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.