Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclin B | 0.012 | 0.5037 | 0.4463 |
Plasmodium falciparum | cyclin | 0.0062 | 0.1035 | 0.5 |
Echinococcus multilocularis | cyclin B | 0.012 | 0.5037 | 0.4463 |
Trichomonas vaginalis | cyclins, putative | 0.012 | 0.5037 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.012 | 0.5037 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.012 | 0.5037 | 0.5 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.012 | 0.5037 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.012 | 0.5037 | 1 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0192 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.012 | 0.5037 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.012 | 0.5037 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.012 | 0.5037 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0192 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.012 | 0.5037 | 1 |
Schistosoma mansoni | cyclin B | 0.012 | 0.5037 | 0.4463 |
Trypanosoma cruzi | cyclin, putative | 0.012 | 0.5037 | 0.5 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.012 | 0.5037 | 0.5 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0192 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.012 | 0.5037 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5037 | 0.4636 |
Trichomonas vaginalis | cyclins, putative | 0.0073 | 0.1782 | 0.1865 |
Schistosoma mansoni | cyclin B3 | 0.0192 | 1 | 1 |
Onchocerca volvulus | 0.012 | 0.5037 | 0.5 | |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.012 | 0.5037 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5037 | 0.4636 |
Entamoeba histolytica | cyclin, putative | 0.012 | 0.5037 | 1 |
Leishmania major | cyclin | 0.012 | 0.5037 | 0.5 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.012 | 0.5037 | 0.5 |
Trichomonas vaginalis | cyclin A, putative | 0.012 | 0.5037 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.012 | 0.5037 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 5 % | Inhibition of GRK-5 (unknown origin)-mediated phosphorylation of rhodopsin in bovine-rod outer segment membranes incubated under white light condition for 15 mins measured after 30 mins by autoradiography in presence of [gamma32P]-ATP | ChEMBL. | 24077529 |
Inhibition (binding) | = 47.2 % | Inhibition of GRK-2 (unknown origin)-mediated phosphorylation of rhodopsin in bovine-rod outer segment membranes at 1 uM incubated under white light condition for 15 mins measured after 30 mins by autoradiography in presence of [gamma32P]-ATP | ChEMBL. | 24077529 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.