Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | adenylate cyclase type IX, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0187 | 0.0211 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0388 | 0.0438 |
Onchocerca volvulus | 0.0054 | 0.0991 | 0.0928 | |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0328 | 0.8855 | 1 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.0187 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | intestinal guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | adenylate cyclase type IX, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase type VI, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0187 | 1 |
Onchocerca volvulus | 0.0328 | 0.8855 | 1 | |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0187 | 1 |
Trichomonas vaginalis | adenylate cyclase type vIII, putative | 0.0033 | 0.0388 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0187 | 1 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.0991 | 1 |
Mycobacterium leprae | Possible transporter protein | 0.0033 | 0.0388 | 1 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0033 | 0.0388 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0187 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase type III, putative | 0.0033 | 0.0388 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0187 | 1 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0187 | 0.0211 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0388 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0187 | 1 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0033 | 0.0388 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase type, putative | 0.0033 | 0.0388 | 0.5 |
Trypanosoma brucei | STE group serine/threonine-protein kinase, putative | 0.0035 | 0.0452 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0187 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0388 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0187 | 0.5 |
Trichomonas vaginalis | adenylate cyclase type IX, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase beta 1 subunit, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0187 | 1 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0033 | 0.0388 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0187 | 1 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0033 | 0.0388 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0033 | 0.0388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0991 | 0.112 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0368 | 1 | 1 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase beta 2 subunit, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase type III, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase type IX, putative | 0.0033 | 0.0388 | 0.5 |
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.0033 | 0.0388 | 1 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylyl cyclase type V, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase type, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0187 | 0.0211 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0033 | 0.0388 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0187 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0187 | 1 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0187 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | adenylate cyclase type, putative | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0033 | 0.0388 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0187 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0388 | 0.5 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0033 | 0.0388 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0187 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 25 uM | Antimalarial activity against ring stage of Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis | ChEMBL. | 24035096 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.