Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | egl-9 family hypoxia-inducible factor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131326 | All targets in OG5_131326 |
Neospora caninum | 2OG-Fe(II) oxygenase family protein, putative | Get druggable targets OG5_131326 | All targets in OG5_131326 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1564 | 1 | 1 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1408 | 0.8892 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0156 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0156 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1564 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.016 | 0.0027 | 0.0027 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0156 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0156 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0156 | 0 | 0.5 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0156 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0156 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0156 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.016 | 0.0027 | 0.0027 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0156 | 0 | 0.5 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1408 | 0.8892 | 1 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.016 | 0.0027 | 0.003 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.016 | 0.0027 | 0.003 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1408 | 0.8892 | 0.8892 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.016 | 0.0027 | 0.0027 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1408 | 0.8892 | 0.8892 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 0.1061 | 0.1061 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0156 | 0 | 0.5 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1408 | 0.8892 | 0.8892 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
F (ADMET) | = 63.2 % | Bioavailability in CD1 mouse at 4 mg/kg, iv | ChEMBL. | 24042008 |
IC50 (binding) | = 0 uM | Inhibition of recombinant PHD2 (unknown origin) using FITC-labeled ACA-DLDLEALAPYIPADDDFQLR as substrate after 1 hr by fluorescence polarization assay | ChEMBL. | 23977883 |
IC50 (binding) | = 1.5 uM | Inhibition of PHD2 (unknown origin) after 30 mins by fluorescence polarization assay | ChEMBL. | 24042008 |
Inhibition (binding) | Inhibition of PHD2 in human Hep3B cells assessed as stabilization of HIF-1alpha at 3 to 100 uM after 24 hrs | ChEMBL. | 24042008 | |
Inhibition (binding) | Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO secretion at 50 uM after 24 hrs by ELISA | ChEMBL. | 24042008 | |
Inhibition (binding) | Inhibition of PHD2 in human Hep3B cells assessed as stabilization of HIF-2alpha at 3 to 100 uM after 24 hrs | ChEMBL. | 24042008 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.