Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.1185 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0098 | 0.1185 | 0.1185 |
Onchocerca volvulus | Deterin homolog | 0.0357 | 1 | 1 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0098 | 0.1185 | 1 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0357 | 1 | 1 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0098 | 0.1185 | 0.1185 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0357 | 1 | 1 |
Onchocerca volvulus | 0.0098 | 0.1185 | 0.1185 | |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0098 | 0.1185 | 0.1185 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1185 | 0.1185 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0098 | 0.1185 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 40 % | Neuroprotective activity against mouse HT22 cells assessed as inhibition of HCA-induced cell injury pretreated at 30 uM for 30 mins measured after 24 hrs by MTT assay | ChEMBL. | 23973819 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.