Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0049 | 0.0693 | 0.0516 |
Plasmodium falciparum | protein kinase 5 | 0.0316 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0316 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0316 | 1 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0034 | 0.0187 | 0.0187 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0316 | 1 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0049 | 0.0693 | 0.0507 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0316 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0049 | 0.0693 | 0.0693 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.9804 | 0.9804 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0292 | 0.9142 | 0.9142 |
Trichomonas vaginalis | AGC family protein kinase | 0.0049 | 0.0693 | 0.0693 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0034 | 0.0187 | 0.0187 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0034 | 0.0187 | 0.0187 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0316 | 1 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0316 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0316 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0316 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0316 | 1 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0034 | 0.0187 | 0.0187 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0316 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0316 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0049 | 0.0693 | 0.0693 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0316 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0316 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0316 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0049 | 0.0693 | 0.0693 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0034 | 0.0187 | 0.0187 |
Echinococcus granulosus | cyclin dependent kinase | 0.0316 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0316 | 1 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0034 | 0.0187 | 0.0187 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0316 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0316 | 1 | 1 |
Mycobacterium leprae | Possible transporter protein | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0049 | 0.0693 | 0.0693 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0316 | 1 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0034 | 0.0187 | 0.0187 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0316 | 1 | 1 |
Onchocerca volvulus | 0.0292 | 0.9142 | 0.5 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0049 | 0.0693 | 0.0693 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0316 | 1 | 1 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0316 | 1 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0316 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0316 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0049 | 0.0693 | 0.0516 |
Trichomonas vaginalis | AGC family protein kinase | 0.0049 | 0.0693 | 0.0693 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0316 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0049 | 0.0693 | 0.0693 |
Entamoeba histolytica | protein kinase, putative | 0.0049 | 0.0693 | 0.0516 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0316 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0316 | 1 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0049 | 0.0693 | 0.0693 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0049 | 0.0693 | 0.0693 |
Brugia malayi | Protein kinase domain containing protein | 0.0316 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0049 | 0.0693 | 0.0693 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 1500 uM | Antitrypanosomal activity against trypomastigote form of Trypanosoma cruzi Y assessed as parasite growth inhibition after 24 hrs by Neubauer cell counting method | ChEMBL. | 24074878 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.