Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1928 | 0.8892 | 0.8892 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0214 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0214 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.2141 | 1 | 1 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0214 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2141 | 1 | 1 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0219 | 0.0027 | 0.003 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0214 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0214 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0214 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0219 | 0.0027 | 0.0027 |
Entamoeba histolytica | hypothetical protein | 0.0214 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0214 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1928 | 0.8892 | 0.8892 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0219 | 0.0027 | 0.0027 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0214 | 0 | 0.5 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0219 | 0.0027 | 0.003 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1928 | 0.8892 | 1 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1928 | 0.8892 | 1 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1928 | 0.8892 | 0.8892 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0219 | 0.0027 | 0.0027 |
Entamoeba histolytica | hypothetical protein | 0.0214 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 58 % | Inhibition of recombinant human BACE1 at 2 uM by FRET analysis | ChEMBL. | 23993670 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.