Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peroxidasin | 0.0063 | 0.0299 | 0.0292 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0253 | 0.243 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.107 | 0.154 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0551 | 0.5784 | 0.8592 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.0299 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0395 | 0.0527 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.0299 | 0.0418 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.0299 | 0.0418 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0253 | 0.243 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.0299 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.107 | 0.154 |
Schistosoma mansoni | amine GPCR | 0.0343 | 0.344 | 0.5046 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0253 | 0.243 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0634 | 0.6714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.0299 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.0529 | 0.0641 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0634 | 0.6714 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.0299 | 0.0383 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0132 | 0.107 | 0.1459 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.0299 | 0.0292 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0358 | 0.3606 | 0.5265 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0634 | 0.6714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.6714 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.0299 | 0.0418 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0253 | 0.243 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0358 | 0.3606 | 0.5265 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0253 | 0.243 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0132 | 0.107 | 0.1403 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0079 | 0.0469 | 0.055 |
Giardia lamblia | Telomerase catalytic subunit | 0.0253 | 0.243 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0132 | 0.107 | 0.1403 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.2517 | 0.3708 |
Brugia malayi | Cache domain containing protein | 0.0072 | 0.0395 | 0.0551 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Schistosoma mansoni | serine-rich repeat protein | 0.0084 | 0.0529 | 0.0641 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Brugia malayi | Blistered cuticle protein 3 | 0.0063 | 0.0299 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0041 | 0.0043 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 0.2852 | 0.421 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0156 | 0.1339 | 0.1866 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0063 | 0.0299 | 0.0383 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0253 | 0.243 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0063 | 0.0299 | 0.0228 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.0299 | 0.0383 |
Brugia malayi | Telomerase reverse transcriptase | 0.0673 | 0.7155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Brugia malayi | Peroxidasin | 0.0063 | 0.0299 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0149 | 0.0159 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0163 | 0.1414 | 0.1926 |
Echinococcus multilocularis | serotonin receptor | 0.0132 | 0.107 | 0.1403 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0163 | 0.1414 | 0.1926 |
Schistosoma mansoni | hypothetical protein | 0.0634 | 0.6714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0198 | 0.0232 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0253 | 0.243 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0299 | 0.0383 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.0299 | 0.0383 |
Brugia malayi | hypothetical protein | 0.0063 | 0.0299 | 0.0418 |
Echinococcus multilocularis | peroxidasin | 0.0063 | 0.0299 | 0.0228 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.02 uM | In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cells | ChEMBL. | 10576684 |
IC50 (binding) | = 0.02 uM | In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cells | ChEMBL. | 10576684 |
IC50 (binding) | = 0.04 uM | In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assay | ChEMBL. | 10576684 |
IC50 (binding) | = 0.04 uM | In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assay | ChEMBL. | 10576684 |
IC50 (binding) | < 0.3 uM | In vitro inhibitory potency against U-937 microsomal COX-1 | ChEMBL. | 10576684 |
IC50 (binding) | < 0.3 uM | In vitro inhibitory potency against U-937 microsomal COX-1 | ChEMBL. | 10576684 |
IC50 (binding) | < 1.2 uM | In vitro inhibitory potency against human COX-1 (HWB COX-2) by whole blood assay | ChEMBL. | 10576684 |
IC50 (binding) | < 1.2 uM | In vitro inhibitory potency against human COX-1 (HWB COX-2) by whole blood assay | ChEMBL. | 10576684 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.