Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase domain containing protein | 0.0905 | 1 | 0.5 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0905 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0905 | 1 | 0.5 |
Onchocerca volvulus | 0.088 | 0.9685 | 0.5 | |
Entamoeba histolytica | casein kinase, putative | 0.0905 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0905 | 1 | 0.5 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0905 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0905 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0905 | 1 | 0.5 |
Leishmania major | casein kinase II, putative | 0.0905 | 1 | 0.5 |
Plasmodium vivax | unspecified product | 0.0905 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0905 | 1 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0905 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0905 | 1 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.0905 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0905 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0905 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0905 | 1 | 0.5 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0905 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0905 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0905 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0905 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC80 (functional) | = 16 ug ml-1 | Antifungal activity against Candida albicans Y0109 assessed as growth inhibition after 24 hr by NCCLS microbroth dilution method | ChEMBL. | No reference |
MIC80 (functional) | = 32 ug ml-1 | Antifungal activity against Candida albicans SC5314 assessed as growth inhibition after 24 hr by NCCLS microbroth dilution method | ChEMBL. | No reference |
MIC80 (functional) | > 64 ug ml-1 | Antifungal activity against Cryptococcus neoformans assessed as growth inhibition after 72 hr by NCCLS microbroth dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.