Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.057 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.057 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.006 | 0.0028 | 0.0028 |
Echinococcus multilocularis | muscleblind protein | 0.0148 | 0.1752 | 0.1752 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1752 | 0.1752 |
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.0511 | 0.8846 | 0.8846 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.006 | 0.0028 | 0.0158 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.0511 | 0.8846 | 0.8846 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1752 | 0.1752 |
Brugia malayi | Muscleblind-like protein | 0.0148 | 0.1752 | 1 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.006 | 0.0028 | 0.0028 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0059 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0059 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0059 | 0 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0148 | 0.1752 | 0.1752 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.057 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0148 | 0.1752 | 0.1752 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0059 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.057 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.61 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 24 hrs by agar microdilution method | ChEMBL. | 24900592 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Cryptococcus neoformans CDRI isolate assessed as growth inhibition after 24 to 48 hrs by microbroth dilution method | ChEMBL. | 24900592 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Candida albicans isolated from patient assessed as growth inhibition after 24 to 48 hrs by microbroth dilution method | ChEMBL. | 24900592 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.