Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0201 | 0.0027 | 0.0027 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.197 | 1 | 1 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0197 | 0 | 0.5 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0201 | 0.0027 | 0.003 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0 | 0.5 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1773 | 0.8892 | 0.8892 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0201 | 0.0027 | 0.003 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1773 | 0.8892 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0197 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0197 | 0 | 0.5 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1773 | 0.8892 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0197 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0201 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1773 | 0.8892 | 0.8892 |
Schistosoma mansoni | serine/threonine protein kinase | 0.197 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0201 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1773 | 0.8892 | 0.8892 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Induction of Bos taurus (bovine) serum albumin degradation after 1 hr by SDS-PAGE analysis | ChEMBL. | No reference | |
IZ (functional) | = 11 mm | Antimicrobial activity against Escherichia coli at 100 ug after 24 hr by cup diffusion technique | ChEMBL. | No reference |
IZ (functional) | = 12 mm | Antimicrobial activity against Saccharomyces cerevisiae at 100 ug after 24 hr by cup diffusion technique | ChEMBL. | No reference |
MIC (functional) | = 10 ug ml-1 | Antimicrobial activity against Saccharomyces cerevisiae after 24 hr by CLSI liquid dilution method | ChEMBL. | No reference |
MIC (functional) | = 10 ug ml-1 | Antimicrobial activity against Escherichia coli after 24 hr by CLSI liquid dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.