Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acyl protein thioesterase 12 | 0.0072 | 0.5 | 0.5 |
Echinococcus multilocularis | acyl protein thioesterase 1 | 0.0072 | 0.5 | 0.5 |
Trypanosoma cruzi | lysophospholipase, putative | 0.0072 | 0.5 | 0.5 |
Loa Loa (eye worm) | phospholipase/Carboxylesterase | 0.0072 | 0.5 | 0.5 |
Toxoplasma gondii | phospholipase/carboxylesterase | 0.0072 | 0.5 | 0.5 |
Trypanosoma brucei | lysophospholipase, putative | 0.0072 | 0.5 | 0.5 |
Schistosoma mansoni | acyl-protein thioesterase 12 (lysophospholipase III) | 0.0072 | 0.5 | 0.5 |
Schistosoma mansoni | acyl-protein thioesterase 12 (lysophospholipase III) | 0.0072 | 0.5 | 0.5 |
Schistosoma mansoni | acyl-protein thioesterase 12 (lysophospholipase III) | 0.0072 | 0.5 | 0.5 |
Trypanosoma cruzi | lysophospholipase, putative | 0.0072 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | esterase | 0.0072 | 0.5 | 0.5 |
Echinococcus granulosus | acyl protein thioesterase 1 | 0.0072 | 0.5 | 0.5 |
Chlamydia trachomatis | lysophospholipase esterase | 0.0072 | 0.5 | 0.5 |
Leishmania major | lysophospholipase, putative | 0.0072 | 0.5 | 0.5 |
Echinococcus granulosus | acyl protein thioesterase 12 | 0.0072 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 24 ug ml-1 | Inhibitory activity against Acid sphingomyelinase | ChEMBL. | 12951083 |
IC50 (binding) | = 24 ug ml-1 | Inhibitory activity against Acid sphingomyelinase | ChEMBL. | 12951083 |
IC50 (binding) | = 72.5 ug ml-1 | Inhibitory activity against NSMase (neutral sphingomyelinase) | ChEMBL. | 12951083 |
IC50 (binding) | = 72.5 ug ml-1 | Inhibitory activity against NSMase (neutral sphingomyelinase) | ChEMBL. | 12951083 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.