TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 524.68 | Formula: C23H40N8O4S
H donors: 7 H acceptors: 4 LogP: 0.42 Rotable bonds: 22
Rule of 5 violations (Lipinski): 3
SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N)CCCC)NC(=O)[C@@H](NC(=O)c1cccs1)CCCNC(=N)N
InChi: 1S/C23H40N8O4S/c1-2-3-8-15(19(25)32)29-20(33)16(9-4-5-12-24)30-21(34)17(10-6-13-28-23(26)27)31-22(35)18-11-7-14-36-18/h7,11,14-17H,2-6,8-10,12-13,24H2,1H3,(H2,25,32)(H,29,33)(H,30,34)(H,31,35)(H4,26,27,28)/t15-,16-,17-/m0/s1
InChiKey: IXZXNBNPEKQWDR-ULQDDVLXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Brugia malayi	larval opioid receptor	0.0271	0.0804	0.0804
Brugia malayi	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0271	0.0804	0.0804
Schistosoma mansoni	neuropeptide receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	somatostatin receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Brugia malayi	Serotonin receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Loa Loa (eye worm)	neuropeptide F receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0271	0.0804	0.0804
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	opsin-like receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	allatostatin A receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Loa Loa (eye worm)	melatonin receptor type 1A	0.0271	0.0804	0.0804
Brugia malayi	hypothetical protein	0.0271	0.0804	0.0804
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0271	0.0804	0.0804
Brugia malayi	ORL1-like opioid receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	g protein coupled receptor	0.0271	0.0804	0.0804
Brugia malayi	G protein-coupled receptor F59B2.13	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	neuropeptide s receptor	0.0271	0.0804	0.0804
Brugia malayi	GnHR receptor homolog	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.0462	0.2055	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus multilocularis	neuropeptide s receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	7tm_1 domain containing protein	0.0271	0.0804	0.0804
Schistosoma mansoni	myosin xvIII	0.0271	0.0804	0.0804
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	neuropeptide receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	g protein coupled receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus multilocularis	fmrfamide receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.1675	1	1
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0271	0.0804	0.0804
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0271	0.0804	0.0804
Onchocerca volvulus		0.0462	0.2055	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Echinococcus granulosus	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0271	0.0804	0.0804
Echinococcus granulosus	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Echinococcus multilocularis	somatostatin receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	biogenic amine receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	neuropeptides capa receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	neuropeptide Y receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0271	0.0804	0.0804
Brugia malayi	RE15519p	0.0271	0.0804	0.0804
Schistosoma mansoni	neuropeptide receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	amine GPCR	0.0271	0.0804	0.0804
Brugia malayi	G-protein coupled receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0271	0.0804	0.0804
Brugia malayi	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus multilocularis	neuropeptides capa receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	biogenic amine receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus multilocularis	orexin receptor type 2	0.0271	0.0804	0.0804
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0271	0.0804	0.0804
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0271	0.0804	0.0804
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0271	0.0804	0.0804
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus granulosus	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Schistosoma mansoni	growth hormone secretagogue receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus granulosus	neuropeptide Y receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0462	0.2055	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0271	0.0804	0.0804
Echinococcus multilocularis	serotonin receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	g-protein coupled receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Echinococcus multilocularis	g-protein coupled receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	neuropeptide receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0271	0.0804	0.0804
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0271	0.0804	0.0804
Brugia malayi	hypothetical protein	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Brugia malayi	neuropeptide F receptor	0.0271	0.0804	0.0804
Brugia malayi	putative neuropeptide receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Schistosoma mansoni	neuropeptide receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus multilocularis	dro:myosuppressin receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0271	0.0804	0.0804
Brugia malayi	Dopamine receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Echinococcus granulosus	neuropeptides capa receptor	0.0271	0.0804	0.0804
Brugia malayi	diacylglycerol acyltransferase family protein	0.0462	0.2055	0.2055
Echinococcus multilocularis	neuropeptide Y receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	g protein coupled receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	hypothetical protein	0.0271	0.0804	0.0804
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0271	0.0804	0.0804
Echinococcus granulosus	g protein coupled receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus granulosus	allatostatin A receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	neuropeptide F receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	0.1675	1	1
Leishmania major	diacylglycerol acyltransferase, putative	0.0462	0.2055	0.5
Brugia malayi	Melatonin receptor type 1A	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus multilocularis	g protein coupled receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus granulosus	neuropeptide FF receptor 2	0.0271	0.0804	0.0804
Schistosoma mansoni	biogenic amine receptor	0.0271	0.0804	0.0804
Brugia malayi	hypothetical protein	0.0271	0.0804	0.0804
Brugia malayi	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus granulosus	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Loa Loa (eye worm)	TYRA-2 protein	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus granulosus	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Schistosoma mansoni	amine GPCR	0.0271	0.0804	0.0804
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0271	0.0804	0.0804
Loa Loa (eye worm)	G-protein coupled receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0271	0.0804	0.0804
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus granulosus	tm gpcr rhodopsin	0.0271	0.0804	0.0804
Echinococcus multilocularis	neuropeptide receptor A26	0.0271	0.0804	0.0804
Toxoplasma gondii	dgat2l1-prov protein	0.0462	0.2055	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0271	0.0804	0.0804
Brugia malayi	Dopamine receptor protein 2	0.0271	0.0804	0.0804
Schistosoma mansoni	amine GPCR	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0271	0.0804	0.0804
Echinococcus granulosus	fmrfamide receptor	0.0271	0.0804	0.0804
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0271	0.0804	0.0804
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0462	0.2055	0.2055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0271	0.0804	0.0804
Schistosoma mansoni	neuropeptide F-like receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Brugia malayi	G protein-coupled receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	serotonin receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	0.1675	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	0.1675	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0271	0.0804	0.0804
Echinococcus granulosus	tm gpcr rhodopsin	0.0271	0.0804	0.0804
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0462	0.2055	0.2055
Schistosoma mansoni	amine GPCR	0.0271	0.0804	0.0804
Echinococcus granulosus	hypothetical protein	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Schistosoma mansoni	neuropeptide F-like receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0148	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus granulosus	sex peptide receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	amine GPCR	0.0271	0.0804	0.0804
Brugia malayi	Serotonin receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	neuropeptides capa receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	histamine h1 receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0462	0.2055	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0271	0.0804	0.0804
Echinococcus granulosus	tm gpcr rhodopsin	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Brugia malayi	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus granulosus	g protein coupled receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	neuropeptide receptor A26	0.0271	0.0804	0.0804
Brugia malayi	follicle stimulating hormone receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0271	0.0804	0.0804
Brugia malayi	G-protein coupled receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Brugia malayi	hypothetical protein	0.0271	0.0804	0.0804
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0271	0.0804	0.0804
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0271	0.0804	0.0804
Schistosoma mansoni	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus granulosus	orexin receptor type 2	0.0271	0.0804	0.0804
Echinococcus granulosus	rhodopsin orphan GPCR	0.0271	0.0804	0.0804
Brugia malayi	sulfakinin receptor protein	0.0271	0.0804	0.0804
Brugia malayi	neuropeptide F receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0271	0.0804	0.0804
Echinococcus granulosus	7TM GPCR rhodopsin	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0271	0.0804	0.0804
Echinococcus granulosus	neuropeptide Y receptor	0.0271	0.0804	0.0804
Brugia malayi	Dopamine receptor protein 1	0.0271	0.0804	0.0804
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0271	0.0804	0.0804
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0271	0.0804	0.0804
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Loa Loa (eye worm)	G-protein coupled receptor	0.0271	0.0804	0.0804
Brugia malayi	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus multilocularis	G protein coupled receptor 139	0.0271	0.0804	0.0804
Schistosoma mansoni	opsin-like receptor	0.0271	0.0804	0.0804
Brugia malayi	hypothetical protein	0.0271	0.0804	0.0804
Schistosoma mansoni	hypothetical protein	0.0271	0.0804	0.0804
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0271	0.0804	0.0804
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0148	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Schistosoma mansoni	adenoreceptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0271	0.0804	0.0804
Echinococcus granulosus	G protein coupled receptor 139	0.0271	0.0804	0.0804
Brugia malayi	AKH receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus granulosus	neuropeptide receptor	0.0271	0.0804	0.0804
Echinococcus multilocularis	serotonin receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	opsin-like receptor	0.0271	0.0804	0.0804
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0271	0.0804	0.0804
Echinococcus granulosus	dro:myosuppressin receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0271	0.0804	0.0804
Schistosoma mansoni	neuropeptide f receptor 76f	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804
Brugia malayi	putative neuropeptide receptor NPR1	0.0271	0.0804	0.0804
Echinococcus multilocularis	sex peptide receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	hypothetical protein	0.0271	0.0804	0.0804
Echinococcus granulosus	biogenic amine 5HT receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0271	0.0804	0.0804
Schistosoma mansoni	neuropeptide receptor	0.0271	0.0804	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0804	0.0804

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)		Inhibition of thrombin (unknown origin) using Boc-Val-Pro-Arg-AMC as substrate at 25 uM after 10 mins by continuous fluorimetric assay	ChEMBL.	24083834

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2440340

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1791918