Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.1578 | 1 | 1 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.1578 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.1113 | 0.6794 | 0.4861 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0673 | 0.3761 | 0.5 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.1578 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0673 | 0.3761 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0673 | 0.3761 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0673 | 0.3761 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0673 | 0.3761 | 0.5 |
Trypanosoma cruzi | casein kinase II, putative | 0.0673 | 0.3761 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.0673 | 0.3761 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0673 | 0.3761 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1578 | 1 | 1 |
Leishmania major | casein kinase II, putative | 0.0673 | 0.3761 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1578 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0673 | 0.3761 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0673 | 0.3761 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0673 | 0.3761 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0673 | 0.3761 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0673 | 0.3761 | 0.5 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.1578 | 1 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.0673 | 0.3761 | 0.5 |
Plasmodium vivax | unspecified product | 0.0673 | 0.3761 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1578 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0673 | 0.3761 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.75 uM | Antimicrobial activity against Trypanosoma cruzi Tulahuen C4 amastigotes infected in rat L6 cells after 96 hrs by beta-galactosidase reporter gene assay | ChEMBL. | 24012457 |
IC50 (functional) | = 3.87 uM | Antimicrobial activity against blood stream form of Trypanosoma brucei rhodesiense STIB 900 after 72 hrs by Alamar blue assay | ChEMBL. | 24012457 |
IC50 (functional) | = 7.8 uM | Antimicrobial activity against Leishmania donovani MHOM-ET-67/L82 amastigotes after 72 hrs by Alamar blue assay | ChEMBL. | 24012457 |
Ratio IC50 (functional) | = 1.2 | Ratio of banznidazole IC50 to compound IC50 for Trypanosoma cruzi Tulahuen C4 amastigotes | ChEMBL. | 24012457 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 24012457 | |
Leishmania donovani | ChEMBL23 | 24012457 | |
Trypanosoma brucei gambiense | 24012457 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.