TDR Targets

Basic information

Technical information

TDR Targets ID: 1792788
Name: 2-methyl-N-[(4-sulfamoylphenyl)carbamothioyl] benzamide
MW: 349.428 | Formula: C15H15N3O3S2
H donors: 3 H acceptors: 3 LogP: 2.45 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: S=C(NC(=O)c1ccccc1C)Nc1ccc(cc1)S(=O)(=O)N
InChi: 1S/C15H15N3O3S2/c1-10-4-2-3-5-13(10)14(19)18-15(22)17-11-6-8-12(9-7-11)23(16,20)21/h2-9H,1H3,(H2,16,20,21)(H2,17,18,19,22)
InChiKey: UAZPOOZIINZDKI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-methyl-N-[[(4-sulfamoylphenyl)amino]-thioxomethyl]benzamide
2-methyl-N-[(4-sulfamoylphenyl)thiocarbamoyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	hypothetical protein	0.0054	0.0013	1
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.3346	0.9838	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Toxoplasma gondii	pyruvate kinase PyK1	0.0071	0.0064	1
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0071	0.0064	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0054	0.0013	0.0014
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0071	0.0064	1
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	TK/INSR protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0054	0.0013	0.0014
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0071	0.0064	0.0052
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	hypothetical protein	0.0054	0.0013	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0013	0.0014
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	hypothetical protein	0.0054	0.0013	1
Loa Loa (eye worm)	hypothetical protein	0.3346	0.9838	1
Entamoeba histolytica	ankyrin repeat protein	0.0054	0.0013	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0054	0.0013	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0013	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0071	0.0064	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	TK/FAK protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	ankyrin repeat protein	0.0054	0.0013	1
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0013	0.0014
Loa Loa (eye worm)	TK/RYK protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0013	0.0014
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	hypothetical protein	0.0054	0.0013	1
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.0013	1
Leishmania major	pyruvate kinase	0.0071	0.0064	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0054	0.0013	0.0014
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.0013	1
Echinococcus granulosus	pyruvate kinase	0.0071	0.0064	0.0052
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0013	0.0014
Loa Loa (eye worm)	hypothetical protein	0.3346	0.9838	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Onchocerca volvulus	Pyruvate kinase homolog	0.0071	0.0064	1
Plasmodium vivax	pyruvate kinase, putative	0.0071	0.0064	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0054	0.0013	0.0014
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.3346	0.9838	1
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0071	0.0064	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0013	0.0014
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0013	0.0014
Entamoeba histolytica	hypothetical protein	0.0054	0.0013	1
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0065
Chlamydia trachomatis	pyruvate kinase	0.0071	0.0064	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	pyruvate kinase	0.0071	0.0064	0.0065
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.3346	0.9838	1
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Brugia malayi	Protein kinase domain containing protein	0.3346	0.9838	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0013	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0013	1
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0054	0.0013	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0013	0.0014
Entamoeba histolytica	hypothetical protein, conserved	0.0054	0.0013	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0054	0.0013	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Schistosoma mansoni	pyruvate kinase	0.0071	0.0064	0.0051
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	hypothetical protein	0.0054	0.0013	1
Entamoeba histolytica	receptor protein kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Mycobacterium ulcerans	pyruvate kinase	0.0071	0.0064	0.5
Trypanosoma brucei	pyruvate kinase 1	0.0071	0.0064	1
Loa Loa (eye worm)	pyruvate kinase	0.0071	0.0064	0.0065
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0054	0.0013	0.0014
Echinococcus multilocularis	pyruvate kinase	0.0071	0.0064	0.0052
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0013	1
Entamoeba histolytica	hypothetical protein	0.0054	0.0013	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0054	0.0013	0.0014
Echinococcus multilocularis	pyruvate kinase	0.0056	0.002	0.0006
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0071	0.0064	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Echinococcus multilocularis	pyruvate kinase	0.0071	0.0064	0.0052
Entamoeba histolytica	cysteine surface protein, putative	0.0054	0.0013	1
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0054	0.0013	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	hypothetical protein	0.0054	0.0013	1
Giardia lamblia	Pyruvate kinase	0.0071	0.0064	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0013	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0013	0.0014
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0013	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	tyrosin kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0013	0.0014
Onchocerca volvulus	Pyruvate kinase homolog	0.0071	0.0064	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0054	0.0013	0.0014
Echinococcus granulosus	pyruvate kinase	0.0071	0.0064	0.0052
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0054	0.0013	0.0014
Trichomonas vaginalis	pyruvate kinase, putative	0.0071	0.0064	1
Schistosoma mansoni	pyruvate kinase	0.0071	0.0064	0.0051
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0013	0.0014
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	hypothetical protein	0.0054	0.0013	1
Entamoeba histolytica	hypothetical protein	0.0054	0.0013	1
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Entamoeba histolytica	receptor protein kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0013	1
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0071	0.0064	0.0052
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0013	0.0014
Trichomonas vaginalis	pyruvate kinase, putative	0.0071	0.0064	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0013	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Leishmania major	pyruvate kinase	0.0071	0.0064	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Entamoeba histolytica	hypothetical protein	0.0054	0.0013	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0013	1
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0054	0.0013	0.0014
Plasmodium falciparum	pyruvate kinase	0.0071	0.0064	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0013	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0013	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0013	0.0014
Entamoeba histolytica	serine/threonine kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	pyruvate kinase	0.0071	0.0064	0.0065
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Trypanosoma brucei	pyruvate kinase 1, putative	0.0071	0.0064	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0013	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0054	0.0013	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0013	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0013	0.0014
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0054	0.0013	1
Entamoeba histolytica	tyrosine kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	SRC-1	0.0054	0.0013	0.0014
Entamoeba histolytica	protein kinase, putative	0.0054	0.0013	1
Loa Loa (eye worm)	TK protein kinase	0.0054	0.0013	0.0014
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0013	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 53 %	Inhibition of Canavalia ensiformis (jack bean) urease assessed as release of ammonia after 30 min by indophenol method	ChEMBL.	No reference
MIC (functional)	= 0.313 ug ml-1	Antibacterial activity against Escherichia coli assessed as growth inhibition after 24 hr by NCCLS broth micro-dilution method	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2298021

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1792788