Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | soluble guanylate cyclase gcy | 0.0149 | 0.8477 | 0.8477 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0062 | 0.1947 | 0.2757 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.0271 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0062 | 0.1947 | 0.1947 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.009 | 0.4015 | 0.5934 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.0271 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0062 | 0.1947 | 0.1947 |
Echinococcus multilocularis | jun protein | 0.009 | 0.4015 | 0.5934 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0125 | 0.6661 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.1381 | 0.1381 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1269 | 0.1269 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0043 | 0.0483 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0057 | 0.0057 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0153 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1075 | 0.1075 |
Schistosoma mansoni | jun-related protein | 0.0073 | 0.2749 | 0.2749 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.0483 | 0.0483 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0062 | 0.1947 | 0.1947 |
Schistosoma mansoni | soluble guanylate cyclase gcy | 0.0051 | 0.1075 | 0.1075 |
Schistosoma mansoni | lipoxygenase | 0.0125 | 0.6661 | 0.6661 |
Schistosoma mansoni | jumonji domain containing protein | 0.0062 | 0.1947 | 0.1947 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0153 | 0.0153 |
Schistosoma mansoni | lipoxygenase | 0.0088 | 0.3831 | 0.3831 |
Schistosoma mansoni | soluble guanylate cyclase gcy | 0.0149 | 0.8477 | 0.8477 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1269 | 0.1269 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0779 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.3829 | 0.3829 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1269 | 0.1269 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0779 | 0.0779 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0043 | 0.0483 | 0.0508 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0125 | 0.6661 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0062 | 0.1947 | 0.2757 |
Loa Loa (eye worm) | guanylyl cyclase/natriuretic peptide receptor | 0.017 | 1 | 1 |
Echinococcus multilocularis | atrial natriuretic peptide receptor 1 | 0.0051 | 0.1075 | 0.1417 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0062 | 0.1947 | 0.2757 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0153 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0153 | 0.0153 |
Schistosoma mansoni | soluble guanylate cyclase gcy | 0.0051 | 0.1075 | 0.1075 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.2749 | 0.2749 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.1947 | 0.1947 |
Brugia malayi | hypothetical protein | 0.0071 | 0.2564 | 0.2564 |
Echinococcus granulosus | atrial natriuretic peptide receptor 1 | 0.0051 | 0.1075 | 0.1417 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1269 | 0.1269 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0153 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0062 | 0.1947 | 0.2757 |
Onchocerca volvulus | 0.017 | 1 | 1 | |
Schistosoma mansoni | soluble guanylate cyclase gcy | 0.0051 | 0.1075 | 0.1075 |
Schistosoma mansoni | soluble guanylate cyclase gcy | 0.017 | 1 | 1 |
Schistosoma mansoni | soluble guanylate cyclase gcy | 0.0149 | 0.8477 | 0.8477 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.7882 | 0.7882 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0153 | 0.5 |
Schistosoma mansoni | soluble guanylyl cyclase beta-3 | 0.0141 | 0.7882 | 0.7882 |
Echinococcus granulosus | jun protein | 0.009 | 0.4015 | 0.5934 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.009 | 0.4015 | 0.5934 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0043 | 0.0483 | 0.0483 |
Brugia malayi | Adenylate and Guanylate cyclase catalytic domain containing protein | 0.0051 | 0.1075 | 0.1075 |
Brugia malayi | jmjC domain containing protein | 0.0062 | 0.1947 | 0.1947 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0153 | 0.0153 |
Brugia malayi | bZIP transcription factor family protein | 0.009 | 0.4015 | 0.4015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.